Current Projects




MeDiTATe aims to develop state-of-the-art image based medical Digital Twins of cardiovascular districts for a patient specific prevention and treatment of aneurysms.

The main objective of MeDiTATe is the production of high-level scientists with a strong experience of integration across academic, industrial and clinical areas, able to apply their skills to real life scenarios and capable to introduce advanced and innovative digital twin concepts in the clinic and healthcare sectors. Recruited researchers will become active players of a strategic sector of the European medical and simulation industry and will face the industrial and research challenges daily faced by clinical experts, engineering analysts and simulation software technology developers.

The Individual Research Projects of the 14 ESRs are defined across five research tracks:
(1) High fidelity CAE multi-physics simulation with RBF mesh morphing (FEM, CFD, FSI, inverse FEM)
(2) Real time interaction with the digital twin by Augmented Reality, Haptic Devices and Reduced Order Models
(3) HPC tools, including GPUs, and cloud-based paradigms for fast and automated CAE processing of clinical database
(4) Big Data management for population of patients imaging data and high fidelity CAE twins
(5) Additive Manufacturing of physical mock-up for surgical planning and training to gain a comprehensive Industry 4.0 approach in a clinical scenario (Medicine 4.0)


Reviews on Non-animal Methods in Use for Biomedical Research in founded by the EU Commission H2020 (JRC/IPR/2018/F.3/0035/OC).

Partners: BiocardioLab, Fondazione Toscana “G Monasterio”, Massa, Italy; RINA Consulting S.p.A.

The main object of the 4R project is to provide a comprensive review of non-animal methods in use for basic and applied research concerning the human Cardiovascular diseases.


The 3D VIRTUAL BABY HEART project (2018-2020) is founded by the Italian Ministry of Health (GR-2016-02365072)

Partners: BiocardioLab, Fondazione Toscana “G Monasterio”, Massa, Italy; adult cardiosurgery and pediatric cardiology units of FTGM and the Laboratory of Perceptual Robotics (PERCRO) of the Scuola  Superiore Sant’Anna, Pisa, Italy.

We pledge to provide a 3D-printed and Virtual replica of any CHD patient’s heart in anticipation of surgery or catheterization.

The main objective od this project is to design an engineering workflow based on 3D Printing techniques and Virtual and Mixed Reality enviroment for supporting physical pre-operative planning

The final goal of this project is to test whether the systematic integration of 3D models in daily practice may change the surgical/interventional approach to complex CHDs defects thus saving times and costs and lately ameliorating outcomes.


“High-speed 3D-imaging of blood vessels based on optical signal processing”

The DIVINE project (2017-2019) is founded by the Fondazione Pisa.

Partners: BiocardioLab, Fondazione Toscana “G Monasterio”, Massa, Italy; adult cardiology unit of FTGM and the TeCIP Institute (PI) of the Scuola  Superiore Sant’Anna, Pisa, Italy.

What the DIVINE project proposes is a fully photonics-based OCT system where both the scanning and data processing operations (with particular reference to A-scan/B-scan and fast Fourier transform) are carried out at very high-speed in the optical domain.

Past Projects


Virtual and Augmented Reality Support for Transcatheter Valve Implantation by using Cardiovascular MRI

The VIVIR project (2017-2019) is founded by the Italian Ministry of health (Ministero della Salute, PE-2013-02357974 grant). 
Partners: BiocardioLab, Fondazione Toscana “G Monasterio”, Massa, Italy; Institute of Cardiovascular Science, UCL (University College London), London, UK; EndoCAS Center, Università di Pisa, Pisa, Italy.

Summary:  Minimally invasive interventions based on transcatheter techniques have dramatically changed the treatment of cardiac valve dysfunction avoiding open-heart surgery.  Bioengineering tools can be applied in this context to support a wider use of this technique and safely spread the related advantages. Realistic patient-specific models will be created as a suitable option to accurately test possible interventions. Cardiac magnetic resonance (MR) imaging will be integrated with computer analyses and navigation systems to plan and execute such interventions on a patient-specific basis. This project involves clinical centres and bioengineering laboratories which will work in synergy to support a translation of patient-specific modelling towards clinical benefits.


“Realizzazione di una valvola aortica polimerica di nuova concezione ed impiantabile tramite piattaforma robotica con tecniche di chirurgia mininvasiva”

The Valvetech project (2016-2018) is founded by the Tuscany Region.

Partners: BiocardioLab, Fondazione Toscana “G Monasterio”, Massa, Italy; adult cardiosurgery units of FTGM, the Laboratory for Biomaterials & Graft Technology of IFC-CNR Institute (PI), the Biorobotic Institute of the Scuola Superiore Sant’Anna, Pisa, Italyand the Endocas center of the University of Pisa.