4R tender

Reviews on Non-animal Methods in Use for Biomedical Research

(JRC/IPR/2018/F.3/0035/OC)

In a nutshell, the outcome of the proposed service will be a collection of non-animal models and methods in use for basic and applied research in the field of human cardiovascular diseases with information on their mechanistic, pathophysiological and biological relevance. The development and/or acceptance status by the research community will also be assessed.

The outcome of the project will be a collection of non-animal models and methods in use for basic and applied research in the field of human cardiovascular diseases with information on their mechanistic, pathophysiological and biological relevance. The development and/or acceptance status by the research community will be also assessed.

The review will cover in vitro methods and in silico approaches applied in cardiovascular research at different levels:

  • cell and tissue based models, including stem-cell technologies; this section will include studies about human-specific cells and sub-cells and tissue based models including two or three dimensional cultures/organotypic models, as well as stem-cell technologies.
  • microfluid circulatory systems and heart- and vasculature-on-a-chip platforms; this section will include studies about microfluidic platforms developed to provide biochemical healthy and diseased models at the organ level that can be applied to disease progression and treatment studies.
  • isolate heart and vessels in-vitro and in-silico models; this section will include in-vitro and in-silico models of cardiovascular organs developed for studies of cardiac and vascular function, valvular disease, heart perfusion.
  • cardiac electrophysiology modeling and simulation; this section will include studies about the integration between electrical and structural components of the heart.
  • cardiovascular system models; this section will include whole heart and vascular system models, assuming a multi-scale and multi-physical approach for understanding cardiac disease development and progression.

Important date

  • 9th February 2019 – Kick off meeting @ JRC, Ispra (IT)