A Precision mEdiciNe-baSed frAMework to pediatric patients with chronic dIseases

  • IFC
  • FTGM
  • AOUM

PENSAMI project is a prospective large-scale multicentre study focused on the secondary prevention of pediatric patients with CD (asthma, diabetes, and congenital heart disease), aims to collect clinics, anthropometric measures at birth, environment, lifestyle, social context, emotional status, mental abilities parameters in order to obtain a predictive model of clinical and non-clinical events as: 1) re-hospitalization; 2) severity and progression of disease; 3) adherence to therapy; 4) ALLEGATO B BANDO RICERCA SALUTE 2018 2 health-related quality of life – HRQoL; 5) obesity and metabolic syndrome; 6) illness-stress related; 7) school drop-out; 8) school performance. PENSAMI hypothesis is that the integrated and multidimensional health framework could be more accurate to: – stratify patients with CD, -to identify patients with higher probability of negative outcomes and could contribute, – to improve HRQoL and to reduce disease progression. PENSAMI approach, in line with precision medicine, aims not only to cure the disease, but to care for the person, with the potential to personalize interventions that cannot be considered only in pharmacological ones, but that take into account subjective changes in psychosocial, environmental and lifestyle assets. From this perspective, the development of a predictive model of clinical and non-clinical events has the following clinical impact: i) to improve disease management and prevention; ii) to better patient outcomes and compliance; iii) to optimize therapeutic strategies through a personalized approach. PENSAMI, thanks to cooperation between clinical and research partners, places the regional health system at the forefront of a process focused on the aggregation and integration of data. PENSAMI will contribute by innovating a model that utilizes data from pre-existing platforms, but in an integrated perspective in order to 1) understand, prevent and halt the progression of childhood CD, 2) develop new and improved diagnostic tools, and 3) pave the way for innovative treatments and therapies additives to traditional clinical practice. The ability to transfer the results of scientific research into clinical practice, in order to meet the needs emerging from the beds of pediatric patients, will allow us to create truly personalized therapeutic and preventive strategies in various sectors such as cardiology, diabetes, and respiratory diseases.