An integrated pipeline for planning of Percutaneous Left Atrial Appendage Occlusion based on 3D printed and in-silico models

Non-Valvular Atrial Fibrillation (NVAF) is a major cause of ischemic strokes. In this context, Oral Anticoagulation (OAC) is the standard treatment for stroke prevention. However, this therapy is applicable only to around 50% of patients. Recently, the percutaneous Left Atrial Appendage Closure Procedure (LAACP) has been developed as an alternative to OAC therapy. The use of this procedure is still limited to a relatively few number of specialized centers, since it still needs a skilled operator trained for the correct selection of new devices and management of the variable and complex LAA morphology.

Aim of the project is to evaluate the usefulness of in-vitro and in-silico simulators for simplifying the clinical planning of LAACP and helping the training of young clinicians. The project could represent the starting point for a prospective, multicenter clinical study leading to the certification of in-vitro/ in-silico simulators as CE-approved medical devices.


  • Fondazione Toscana G. Monasterio
  • Politecnico di Milano
  • ASL4 Liguria


Kick Off Meeting – April 18th 2023


This research was funded by the Italian Ministry of Health
grant number RF-2021-12375208