PLACE

An integrated pipeline for planning of Percutaneous Left Atrial Appendage Occlusion based on 3D printed and in-silico models

Non-Valvular Atrial Fibrillation (NVAF) is a major cause of ischemic strokes. In this context, Oral Anticoagulation (OAC) is the standard treatment for stroke prevention. However, this therapy is applicable only to around 50% of patients. Recently, the percutaneous Left Atrial Appendage Closure Procedure (LAACP) has been developed as an alternative to OAC therapy. The use of this procedure is still limited to a relatively few number of specialized centers, since it still needs a skilled operator trained for the correct selection of new devices and management of the variable and complex LAA morphology.

Aim of the project is to evaluate the usefulness of in-vitro and in-silico simulators for simplifying the clinical planning of LAACP and helping the training of young clinicians. The project could represent the starting point for a prospective, multicenter clinical study leading to the certification of in-vitro/ in-silico simulators as CE-approved medical devices.

Partners

• Fondazione Toscana G. Monasterio
• Politecnico di Milano

• ASL4 Liguria

PLACE TEAM

Sergio Berti (MD) – Simona Celi (MSE) – Benigno Marco Fanni (MSE) – Emanuele Gasparotti (MSE) – Ilaria Verdirame (MSE) – Rossana Buongiorno (MSE) – Augusto Esposito (MD) –  Lorenza Petrini (MSE) – Giancarlo Pennati (MSE) – Francesca Berti (MSE) – Francesca Danielli (MSE) – Guido Parodi (MD)

NEWS

Kick Off Meeting – April 18th 2023

Best poster award (Runner UP) 29th Congress of the European Society of Biomechanics, June 30 – July 3, 2024, Edinburgh, Scotland: Emanuele Gasparotti, Benigno Marco Fanni, Mattia Dell’amico, Francesca Danielli, Francesca Berti, Giancarlo Pennati, Lorenza Petrini, Simona Celi, Design and fabrication of deformable 3d printed model of patient-specific left atrium for PIV investigation

Best Oral presentation ESB-ITA 2024, XIII Annual Meeting Italian Chapter of the European Society of Biomechanics 3 – 4 October 2024, Pescara, Italy: I. Verdirame, B. M. Fanni, R. Buongiorno, F. Dell’Agnello, S. Berti, F. Cademartiri, G. Parodi, F. Danielli, F. Berti, G. Pennati, L. Petrini and S. Celi “Study of left atrial appendage hemodynamics by integrating time-resolved CT and mesh”

 

PUBLICATIONS

1. Fanni, B.M., Gasparotti, E., Esposito, A., Danielli, F., Berti, F., Berti, S., Pennati, G., Petrini, L. and Celi, S. (2024), “A high-fidelity personalised 3d printed simulator for the left atrial appendage occlusion procedure”, Rapid Prototyping Journal, Vol. ahead-of-print No. ahead-of-print. https://doi.org/10.1108/RPJ-03-2024-0126
2. Danielli, F., Berti, F., Fanni, B. M., Gasparotti, E., Celi, S., Pennati, G., & Petrini, L. (2024). Left atrial appendage occlusion: On the need of a numerical model to simulate the implant procedure. International Journal for Numerical Methods in Biomedical Engineering, e3814. doi: 10.1002/cnm.3814.
3. E. Gasparotti et al, Computational Fluid Dynamic Simulation to Evaluate the Device-Related Effects After Left Atrial Appendage Occlusion, Lecture Notes in Computational Vision and Biomechanics, 2024, 39, pp. 205–212

CONFERENCES

CMBBE 2023

• Emanuele Gasparotti, Benigno Marco Fanni, Katia Capellini, Alberto Clemente, Sergio Berti and Simona Celi  “NUMERICAL SIMULATIONS TO EVALUATE THE DEVICE-RELATED EFFECTS IN ATRIAL FIBRILLATION PATIENTS ”, CMBBE 2023 SYMPOSIUM, 18th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering, 3 – 5 May 2023 in Paris, France https://www.cmbbe-symposium.com/2023/wp-content/uploads/sites/14/2023/04/CMBBE23_Abstract_book_orals_small.pdf

• Francesca Danielli, Benigno Marco Fanni, Emanuele Gasparotti, Lorenza Petrini, Giancarlo Pennati, Francesca Berti “A DISCUSSION ON STRATEGIES FOR THE IN SILICO DEPLOYMENT OF LEFT ATRIAL APPENDAGE OCCLUDERS”, CMBBE 2023 SYMPOSIUM, 18th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering, 3 – 5 May 2023 in Paris, France https://www.cmbbe-symposium.com/2023/wp-content/uploads/sites/14/2023/04/CMBBE23_Abstract_book_orals_small.pdf

ESB 2023

• Fanni, Benigno Marco; Gasparotti, Emanuele; Capellini, Katia; Danielli, Francesca; Berti, Francesca; Berti, Sergio; Pennati, Giancarlo; Petrini, Lorenza; Celi, Simona A NUMERICAL WORKFLOW TO INVESTIGATE THE HEMODYNAMICS EFFECTS OF THE LEFT ATRIAL APPENDAGE OCCLUSION https://esbiomech.org/conference/esb2023/paper-abstracts/
• Danielli, Francesca; Berti, Francesca; Fanni, Benigno Marco; Gasparotti, Emanuele; Celi, Simona; Pennati, Giancarlo; Petrini, Lorenza ON THE NEED OF A RELIABLE NUMERICAL MODEL TO SIMULATE THE LEFT ATRIAL APPENDAGE OCCLUSION: A FINITE ELEMENT STUDY https://esbiomech.org/conference/esb2023/paper-abstracts/

EUSOMII 2023

• B.M. Fanni, E. Gasparotti,  A. Esposito , F. Danielli , F. Berti, S. Berti, G. Pennati, L. Petrini and S. Celi, 3D Printing for the Training and Pre-Procedural Planning of the Left Atrial Appendage Occlusion,  EuSoMII Annual Meeting 202, Pisa, Italy, 13-14 October 2023

ESB 2024

• Emanuele Gasparotti, Benigno Marco Fanni, Mattia Dell’amico, Francesca Danielli, Francesca Berti, Giancarlo Pennati, Lorenza Petrini, Simona Celi, Design and fabrication of deformable 3d printed model of patient-specific left atrium for PIV investigation,  29th Congress of the European Society of Biomechanics, June 30 – July 3, 2024, Edinburgh, Scotland https://esbiomech2024.org/wp-content/uploads/sites/20/2024/06/ESB_2024_conference_brochure.pdf
• Benigno Marco Fanni, Ilaria Verdirame, Katia Capellini, Francesca Dell’Agnello, Marilena Mazzoli, Simone Garzia, Francesca Danielli, Francesca Berti, Giancarlo Pennati, Lorenza Petrini, Simona Celi, AN IMAGE-BASED IN-SILICO PIPELINE FOR THE PATIENT-SPECIFIC SIMULATION OF THE LEFT ATRIAL HEMODYNAMICS, 29th Congress of the European Society of Biomechanics, June 30 – July 3, 2024, Edinburgh, Scotland https://esbiomech2024.org/wp-content/uploads/sites/20/2024/06/ESB_2024_conference_brochure.pdf

IDBN 2024

• Emanuele Gasparotti, Benigno Marco Fanni, Mattia Dell’Amico, Augusto Esposito, Francesca Danielli, Francesca Berti, Guido Parodi, Giancarlo Pennati, Lorenza Petrini, Sergio Berti, Simona Celi, Il ruolo della stampa 3D nella pianificazione e nel training della chiusura dell’auricola sinistra, IV Congresso Nazionale IDBN – Italian Digital Biomanufacturing Network 26-27 Settembre 2024, Firenze, Italia https://idbn.org/wp-content/uploads/2024/09/IDBN2024_Libro-degli-Abstract.pdf

ESB-ITA 2024

• Rossana Buongiorno, Ilaria Verdirame, Benigno Marco Fanni, Francesca Dell’Agnello, Katia Capellini and Simona Celi, An Optimized Framework Integrating Residual 3D-UNet To Segment Left Atrial Appendage For Wall Motion Estimation, ESB-ITA 2024, XIII Annual Meeting Italian Chapter of the European Society of Biomechanics 3 – 4 October 2024, Pescara, Italy
• I. Verdirame, B. M. Fanni, R. Buongiorno, F. Dell’Agnello, S. Berti, F. Cademartiri, G. Parodi, F. Danielli, F. Berti, G. Pennati, L. Petrini and S. Celi “Study of left atrial appendage hemodynamics by integrating time-resolved CT and mesh”, ESB-ITA 2024, XIII Annual Meeting Italian Chapter of the European Society of Biomechanics 3 – 4 October 2024, Pescara, Italy https://www.esb-ita.it/wp-content/uploads/2024/10/ProgrammaDefinitivo-4.pdf

ICMMB 2024

• Francesca Danielli, Benigno Marco Fanni, Emanuele Gasparotti, Simona Celi, Lorenza Petrini, Giancarlo Pennati, Francesca Berti, “Patient-specific in silico modeling of the left atrial appendage occlusion”, XXIII International Conference on Mechanics in Medicine and Biology – ICMMB, Bruxelles, Belgium, September 11-13, 2024 https://icmmb2024.ulb.be/wp-content/uploads/2024/09/ICMMB2024_Scientific_Program.pdf

VPH 2024

• Francesca Danielli, Francesca Berti, Benigno Marco Fanni, Emanuele Gasparotti, Andrea Colella, Alessandro Vitozzi, Simona Celi, Giancarlo Pennati, Lorenza Petrini, “LEFT ATRIAL APPENDAGE OCCLUSION: A VIRTUAL MODEL TO SIMULATE THE IMPLANT PROCEDURE IN PATIENT-SPECIFIC SCENARIOS”, VPH 2024, 4-6 September 2024, Stuttgart, Germany

 

This research was funded by the Italian Ministry of Health
grant number RF-2021-12375208